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  • Writer's picturePat Browne

SMART GPS® OVERCOMES THE BIGGEST CHALLENGE OF SKINCARE

Updated: Sep 28, 2022

The most difficult challenge for all forms of topical skincare is the penetration of the stratum corneum. Developed at the INNOAESTHETICS Laboratory, Smart GPS® (Guidance Performance System) is cutting-edge skincare technology that achieves better penetration of the stratum corneum.

Moving beyond the stratum corneum allows for active ingredients to penetrate deeper within the skin’s cell structure. By imitating the physical-chemical characteristics of the surface of the epidermis, Smart GPS® overcomes the stratum corneum’s natural resistance without damaging it. Then through encapsulation technology, Smart GPS® conveys and delivers active ingredients to the target cell groups for maximum therapeutic effect. Encapsulation has the added benefit of ensuring stability of active ingredients and protects from degradation.


There are two main aims of Smart GPS® technology:

1) To create a perfect affinity with the hydrolipidic film on the surface of the stratum corneum (lipids with corneocyte adhesive components and aqueous components with keratinocytes).


A continuous film on the surface of the skin boosts the skin’s barrier effect, slowing down TEWL(1) and producing a moisturizing hygroscopic action(2).


2) To allow the disorganization of the lipids located between the corneocytes so that penetration of encapsulated active ingredients can spread beyond the stratum corneum.


This improves the bioavailability of the active ingredients within the skin’s epidermis; limits passive molecular diffusion; improves active ingredient dosing and ensures that target substances remain in the contact area.


Continuous research has proven the validity of the assumption.


The examples below demonstrate the effectiveness of epidermal penetration of active ingredients with Smart GPS® vs without. The difference between the control and the study product demonstrates how Smart GPS® guides the product through the stratum corneum allowing for a diffusion of active ingredients.

SKIN PENETRATION

The bio-vector assimilates into hydrophilic protein cells (the lipids located between the corneocytes) as required. When Smart GPS® is present, the drop on the skin does not encounter any type of resistance, it disperses and is fully absorbed into the skin.


MOSITURIZING EFFECT


REDUCES WATER EVAPORATION

The skin’s ability to hold moisture is improved by the reduction in TEWL(2). Smart GPS® enhances the hydrolipidic film on the epidermis. It is proven to enhance the lipids located between the corneocytes among the hydrophilic protein cells.


INCREASES WATER FIXING AS IT PASSES THROUGH THE STRATUM CORNEUM


Smart GPS® hygroscopic power allows it to retain a quantity of water 5X its own mass, much more than the standard hydrophobic products on the market.


INCREASES KERATINOCYTE COHESION

Skin treated with Smart GPS® shows greater cohesion of keratinocytes causing enhanced resistance to physical and mechanical change.


Tissue pre-treated with Smart GPS® show greater resistance to detachment, and keratinocyte cohesion is higher than with standard hydrophobic products:

+ 12% compared to Vaseline

+ 25% compared to paraffin

+ 19% compared to silicone


CUMMULATIVE MOISTURIZING EFFECT

Smart GPS® provides greater moisturizing effect than even hyaluronic acid – the gold standard of advanced moisturizing.


Hygroscopic products, such as sorbitol, glycerin, or hyaluronic acid, have a higher moisturizing effect than hydrophobic products, but less than Smart GPS®, which imitates the skin’s natural function, and has a dual mechanism:

• It slows down insensible water loss.

• It absorbs several times its own mass in water, subsequently maintaining the skin’s surface humidity.


DIFFUSION OF ACTIVE INGREDIENTS

Studies demonstrate the efficiency of Smart GPS® in terms of molecular diffusion (in vivo). After application and rinsing, the hand stained with Smart GPS® remained in the skin’s middle layers just below the surface of the stratum corneum.


After the staining test and rinsing, the stain had totally disappeared for the control case (stain without Smart GPS – top row), whereas the stain remained in the skin’s middle in the sample with Smart GPS®.


SKIN PENETRATION LEVEL

Without Smart GPS®, a cherry red stain sits as a ball on the surface of the skin with limited diffusion. Ultrasound-imagery shows the die remains exclusively on the surface with no penetration.


The skin treated with Smart GPS® tells a completely different story. From the beginning, the drop disperses across the skin’s surface and quickly absorbs into the skin. The ultrasound-imagery shows the pink staining from the die has transferred within the skin, collecting at the bottom of the stratum corneum.


SAFETY ON THE SKIN

Safety data from repeated trials show that when applied to either skin or mucous membranes Smart GPS® is innocuous and does not cause irritation or hypersensitivity both in vivo or in vitro.


KEY BENEFITS

  1. Smart GPS® is easily broken down to molecules that assimilate naturally into the skin.

  2. Smart GPS® is safe and does not cause irritation or reaction to the skin.

  3. Smart GPS® is a bio-vector for every molecule, meaning all forms of active ingredients are released into the skin’s middle layer.

  4. Smart GPS®’s hydrophilic and lipophilic components allow it to behave naturally in intercellular spaces, enabling the transportation and delivery of active ingredients.

  5. Smart GPS® is proven to stimulate the active molecular diffusion through the epidermis’ corneal layer.

  6. Smart GPS® improves results by ensuring active ingredients remain in the skin’s middle layer, avoiding passive diffusion outside the chosen zone.

FOOT NOTES:

  1. Trans-epidermal water loss (TEWL) represents a measure of water passing out of the epidermis not related to sweating can be a measure of the effectiveness of the barrier properties of the stratum corneum.

  2. Hygroscopy is the phenomenon of attracting and holding water molecules via either absorption or adsorption from the surrounding environment.

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